Ammonia → 2-(6-Methoxy-2-naphthyl)propanamide

HRID 372925Notes

Reaction equation

HRID 372925 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:17])[C:14](Cl)=[O:15])[CH:7]=[CH:6]2.[NH3:18]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:17])[C:14]([NH2:18])=[O:15])[CH:7]=[CH:6]2

Participants

4

Reactant 2

HCID 222AmmoniaHCID 101988292-(6-methoxynaphthalen-2-yl)propanoyl Chloride

Product 1

HCID 6040272-(6-Methoxy-2-naphthyl)propanamide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Into 300 ml of dry toluene, were dissolved 10.8 g of oa (6-methoxy-2-naphthyl)-propanoic acid chloride, followed by introducing dry ammonia at a temperature not more than 15° C. for 30 minutes. Stirring was continued at room temperature for 3 hours, and then precipitated while solid was filtered off. The resulting white solid was washed with toluene and then water, followed by recrystallizing with ethanol to obtain 10.0 g of oa (6-methoxy-2-naphthyl)-propanamide.

Workup

  1. customprecipitated while solid
  2. filtrationwas filtered off
  3. washThe resulting white solid was washed with toluene
  4. customby recrystallizing with ethanol

Sources & evidence

ORD record
ord-f4821cb5b64549c6a13ccd1a3eaf1660
Source dataset
uspto-grants-1992_11
Patent number
US05160662

Reaction notes

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