p-(1-Trifluoromethylheptyloxy)nitrobenzene → p-(1-Trifluoromethylheptyloxy)-aniline

HRID 372932Notes

Reaction equation

HRID 372932 reaction equation
[F:1][C:2]([F:21])([F:20])[CH:3]([O:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[H][H]>[Pd].C(O)C>[F:1][C:2]([F:20])([F:21])[CH:3]([O:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

5

Reactant 2

HCID 15123947p-(1-Trifluoromethylheptyloxy)nitrobenzeneHCID 178418361HCID 178418361, compound

Product 1

HCID 15123948p-(1-Trifluoromethylheptyloxy)-aniline

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To 100 ml of dry ethanol containing 77.7 g of oa p-(1-trifluoromethyl-heptyloxy)-nitrobenzene, was added 0.5 g of 5% Pd/C (5% palladium carbon) followed by carrying out reduction within an atmosphere of hydrogen at normal pressure under stirring at room temperature. After it was confirmed that no absorption of hydrogen was observed, the catalyst was removed by filtration and then the ethanol was distilled off to obtain 6.7 g of oily oa p-(1-trifluoromethylheptyloxy)-aniline.

Workup

  1. customAfter it was confirmed that no absorption of hydrogen
  2. customthe catalyst was removed by filtration
  3. distillationthe ethanol was distilled off

Sources & evidence

ORD record
ord-3cdbc7495be245c7b1444aba18c1824c
Source dataset
uspto-grants-1992_11
Patent number
US05160662

Reaction notes

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