Ammonia → Amino 4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4.5-d]pyrimidine

HRID 372980Notes

Reaction equation

HRID 372980 reaction equation
CS[C:3]1[N:8]=[C:7]2[N:9]=[C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])[NH:11][C:12](=[O:13])[C:6]2=[CH:5][N:4]=1.[NH3:24]>>[NH2:24][N:11]1[C:12](=[O:13])[C:6]2[C:7](=[N:8][CH:3]=[N:4][CH:5]=2)[N:9]=[C:10]1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:20][CH2:21][CH2:22][CH3:23]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 1355223017-Methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine

Product 1

HCID 19811303Amino 4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4.5-d]pyrimidine

Procedure

7-Methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (1.55 g) was heated in ethanolic ammonia (50 ml) in a pressure vessel for 8 hours at 90° C. and then for 8 hours at 145° C. After cooling a grey solid (0.64 g) was collected and was recrystallised from ethanol (with charcoal) to yield a crude product (0.47 g) which was recrystallised from ethanol to yield the title compound, 0.29 g, m.p. 261°-262° C.

Workup

  1. customwas collected
  2. customwas recrystallised from ethanol (with charcoal)
  3. customto yield a crude product (0.47 g) which
  4. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-338ac642b2be45d7baa0fb7071145d72
Source dataset
uspto-grants-1992_11
Patent number
US05162316

Reaction notes

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