HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 7-Methylamino-2-(2-methoxyphenyl)-4-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 7-Methylthio-2-(2-methoxyphenyl)-4-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine | HCID 135670766 | — |
| Product | 7-Methylamino-2-(2-methoxyphenyl)-4-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine | HCID 136008642 | — |
Reaction Steps
In a similar manner to Example 8 reaction of 7-methylthio-2-(2-methoxyphenyl)-4-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine (0.75 g) and 33% methylamine in industrial methylated spirit (25 ml) for 18 hours yielded the title compound, 0.38 g, m.p. 265°-267° C. (recrystallised twice from methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05162316 |
| Source dataset | uspto-grants-1992_11 |
| ORD ID | ord-268f33265d1045bda9f9d5c2673c175e |
| Source note | uspto-grants-1992_11 |