Morpholine → HCID 136170719, compound

HRID 372988Notes

Reaction equation

HRID 372988 reaction equation
CS[C:3]1[N:8]=[C:7]2[N:9]=[C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])[NH:11][C:12](=[O:13])[C:6]2=[CH:5][N:4]=1.[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>N1C=CC=CC=1>[O:27]1[CH2:28][CH2:29][N:24]([C:3]2[N:8]=[C:7]3[N:9]=[C:10]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=4[O:20][CH2:21][CH2:22][CH3:23])[NH:11][C:12](=[O:13])[C:6]3=[CH:5][N:4]=2)[CH2:25][CH2:26]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 1355223017-Methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine

Product 1

HCID 136170719HCID 136170719, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A stirred solution of 7-methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.60 g) and morpholine (1.25 g) in pyridine (20 ml) was heated under reflux for 45 hours. The reaction mixture was evaporated under reduced pressure to yield a crude product which was washed with water and twice recrystallised from methanol to yield the title compound, 0.25 g, m.p. 175.5°-177° C.

Workup

  1. temperatureunder reflux for 45 hours
  2. customThe reaction mixture was evaporated under reduced pressure
  3. customto yield a crude product which
  4. washwas washed with water
  5. customtwice recrystallised from methanol

Sources & evidence

ORD record
ord-6737837a71204a81b147e61f2bd2e6c9
Source dataset
uspto-grants-1992_11
Patent number
US05162316

Reaction notes

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