Sodium Methoxide → HCID 135670792, compound

HRID 373001Notes

Reaction equation

HRID 373001 reaction equation
CS([C:5]1[N:10]=[C:9]2[N:11]=[C:12]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[O:22][CH2:23][CH2:24][CH3:25])[NH:13][C:14](=[O:15])[C:8]2=[CH:7][N:6]=1)(=O)=O.[CH3:26][O-:27].[Na+]>>[CH3:26][O:27][C:5]1[N:10]=[C:9]2[N:11]=[C:12]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[O:22][CH2:23][CH2:24][CH3:25])[NH:13][C:14](=[O:15])[C:8]2=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 10942334Sodium MethoxideHCID 1356707527-Methylsulphonyl-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine

Product 1

HCID 135670792HCID 135670792, compound

Procedure

In a similar manner to Example 36 reaction of 7-methylsulphonyl-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.50 g) and sodium methoxide solution (from sodium, 0.16 g, and methanol, 20 ml) yielded the title compound, 0.29 g, m.p. 231°-2°° C. (recrystallised from methanol).

Sources & evidence

ORD record
ord-26b1a9450ea44dec9d813d354eb0fb08
Source dataset
uspto-grants-1992_11
Patent number
US05162316

Reaction notes

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