反应详情

Following the procedures of Example 1, the title compound is prepared. Thus, a mixture of 5-(4-chlorobutyl)-3-methyl-2-oxazolidinone (5.0 g, 0.0262 mol), 1-(2-methoxyphenyl)piperazine (5.4 g. 0.0279 mol), potassium carbonate (8.5 g, 0.0614 mol), and potassium iodide (0.75 g) in 1-butanol (50 ml) gave 6.8 g of oil which was dissolved in hot methanol and acidified with methanolic hydrogen chloride. Addition of isopropyl ether and isopropanol to the cloud point and cooling gave a solid which was collected by filtration, rinsed with isopropyl ether and light pet ether and dried under high vacuum to give 4.22 g (38% yield), mp 209°-216° C.