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Potassium Iodide → 3-Methyl-5-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2-oxazolidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Piperazinylpyrimidine dihydrochloride | HCID 11680272 | — |
| 反応物 | 5-(4-Chlorobutyl)-3-methyl-2-oxazolidinone | HCID 19811462 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 3-Methyl-5-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2-oxazolidinone | HCID 19811469 | 35.8% |
反応手順
Following the procedure of Example 1, mixture of 5-(4-chlorobutyl)-3-methyl-2-oxazolidinone (5.0 g, 0.0262 mol), 1-(2-pyrimidinyl)piperazine dihydrochloride (6.62 g, 0.0279 mol), potassium carbonate (19.3 g, 0.140 mol) and potassium iodide (0.75 g) in 1-butanol (75 ml) gave an oil (3.0 g) which crystallized upon standing. Recrystallization from ethyl acetate/light pet ether followed by drying under high vacuum gave 1.33 g (16% yield), mp 74°-76° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05162322 |
| 出典データセット | uspto-grants-1992_11 |
| ORD ID | ord-690eec9aadc4444d83693cbe9e4ec9b6 |
| 出典メモ | uspto-grants-1992_11 |