Potassium Iodide → HCID 19811485, Verbindung

HRID 373016Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 373016
Cl[CH2:2][CH2:3][CH2:4][CH:5]1[O:9][C:8](=[O:10])[N:7]([CH3:11])[CH2:6]1.Cl.Cl.[N:14]1[CH:19]=[CH:18][CH:17]=[N:16][C:15]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(O)CCC>[CH3:11][N:7]1[CH2:6][CH:5]([CH2:4][CH2:3][CH2:2][N:23]2[CH2:24][CH2:25][N:20]([C:15]3[N:14]=[CH:19][CH:18]=[CH:17][N:16]=3)[CH2:21][CH2:22]2)[O:9][C:8]1=[O:10]

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 116802722-Piperazinylpyrimidine dihydrochlorideHCID 198114995-(3-Chloropropyl)-3-methyl-2-oxazolidinone

Produkt 1

HCID 19811485HCID 19811485, VerbindungAusbeute 41 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

Following the procedure of Examples 5, 5-(3-chloropropyl)-3-methyl-2-oxazolidinone (5.0 g, 0.0282 mol), 1-(2-pyrimidinyl)piperazine dihydrochloride (6.70 g, 0.0282 mol), potassium carbonate (23.4 g, 0.1695 mol), and potassium iodide (0.5 g) in 1-butanol (100 mL) gave an oil (3.5 g, 41% yield) which was dissolved in a hot mixture of isopropyl ether and isopropanol, filtered hot, and brought to the cloud point by the addition of light pet ether. Upon cooling, a solid precipitated which was collected by filtration, rinsed with light pet ether, and dried under high vacuum to give 1.38 g, mp 79°-89° C.

Quellen und Nachweise

ORD-Eintrag
ord-4c0bdad91d00463e9bf0542ac024213e
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05162322

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