反应详情

Following the procedure of Examples 5, 5-(3-chloropropyl)-3-methyl-2-oxazolidinone (5.0 g, 0.0282 mol), 1-(2-pyrimidinyl)piperazine dihydrochloride (6.70 g, 0.0282 mol), potassium carbonate (23.4 g, 0.1695 mol), and potassium iodide (0.5 g) in 1-butanol (100 mL) gave an oil (3.5 g, 41% yield) which was dissolved in a hot mixture of isopropyl ether and isopropanol, filtered hot, and brought to the cloud point by the addition of light pet ether. Upon cooling, a solid precipitated which was collected by filtration, rinsed with light pet ether, and dried under high vacuum to give 1.38 g, mp 79°-89° C.