Potassium Iodide → 5-[4-[4-(2-Hydroxyphenyl)-1-piperazinyl]butyl]-3-methyl-2-oxazolidinone

HRID 373020Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 373020
Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]1[O:10][C:9](=[O:11])[N:8]([CH3:12])[CH2:7]1.Br.Br.[OH:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.C(=O)(O)[O-].[Na+].[I-].[K+]>C(O)CCC>[OH:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:27][CH2:26][N:25]([CH2:2][CH2:3][CH2:4][CH2:5][CH:6]2[O:10][C:9](=[O:11])[N:8]([CH3:12])[CH2:7]2)[CH2:24][CH2:23]1

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 516892Sodium BicarbonateHCID 3017100o-(1-Piperazinyl)phenol dihydrobromideHCID 198114625-(4-Chlorobutyl)-3-methyl-2-oxazolidinone

Produkt 1

HCID 198115015-[4-[4-(2-Hydroxyphenyl)-1-piperazinyl]butyl]-3-methyl-2-oxazolidinoneAusbeute 34 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

Following the procedure of Example 5, a mixture of 5-(4-chlorobutyl)-3-methyl-2-oxazolidinone (5.39 g, 0.0282 mol), 1-(2-hydroxyphenyl)-piperazine dihydrobromide (9.6 g, 0.0282 mol), sodium bicarbonate (9.5 g, 0.113 mol) and potassium iodide (1.0 g) in n-butanol (100 mL) gave an oil which was triturated in light pet ether several times, crystallized from ethyl acetate/isopropyl ether, and dried under high vacuum at 50° C. to give 3.22 g (34% yield), mp 106°-110°.

Aufarbeitung

  1. customgave an oil which
  2. customwas triturated in light pet ether several times
  3. customcrystallized from ethyl acetate/isopropyl ether
  4. customdried under high vacuum at 50° C.
  5. customto give 3.22 g (34% yield), mp 106°-110°

Quellen und Nachweise

ORD-Eintrag
ord-8bd77ef122124e56afd60fffdb577238
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05162322

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