反应详情

Following the procedure of Example 5, a mixture of 5-(4-chlorobutyl)-3-methyl-2-oxazolidinone (5.39 g, 0.0282 mol), 1-(2-hydroxyphenyl)-piperazine dihydrobromide (9.6 g, 0.0282 mol), sodium bicarbonate (9.5 g, 0.113 mol) and potassium iodide (1.0 g) in n-butanol (100 mL) gave an oil which was triturated in light pet ether several times, crystallized from ethyl acetate/isopropyl ether, and dried under high vacuum at 50° C. to give 3.22 g (34% yield), mp 106°-110°.

1. customgave an oil which
2. customwas triturated in light pet ether several times
3. customcrystallized from ethyl acetate/isopropyl ether
4. customdried under high vacuum at 50° C.
5. customto give 3.22 g (34% yield), mp 106°-110°