Potassium Iodide → 3-Phenyl-5-[3-[4-(2-pyridinyl)-1-piperazinyl]propyl]-2-oxazolidinone

HRID 373026ノート

反応式

HRID 373026 の反応式
Cl[CH2:2][CH2:3][CH2:4][CH:5]1[O:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:6]1.[N:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(O)CCC>[C:11]1([N:7]2[CH2:6][CH:5]([CH2:4][CH2:3][CH2:2][N:26]3[CH2:27][CH2:28][N:23]([C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][N:17]=4)[CH2:24][CH2:25]3)[O:9][C:8]2=[O:10])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 944591-(2-Pyridyl)piperazineHCID 198114805-(3-Chloropropyl)-3-phenyl-2-oxazolidinone

生成物 1

HCID 198114613-Phenyl-5-[3-[4-(2-pyridinyl)-1-piperazinyl]propyl]-2-oxazolidinone収率 56%

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

Following the procedure of Example 5, a mixture of 5-(3-chloropropyl)-3-phenyl-2-oxazolidinone (4.5 g, 0.0188 mol), 1-(2-pyridinyl)piperazine (3.07 g, 0.0188 mol), potassium carbonate (7.81 g, 0.0565 mol), and potassium iodide (1.0 g) in n-butanol (200 mL) gave a solid which was recrystallized from isopropanol/isopropyl ether and dried under high vacuum to give 3.86 g (56% yield), mp 123°-125° C.

後処理

  1. customgave a solid which
  2. customwas recrystallized from isopropanol/isopropyl ether
  3. customdried under high vacuum
  4. customto give 3.86 g (56% yield), mp 123°-125° C.

出典と根拠

ORDレコード
ord-6515b6fad796417e958235f8d6818363
出典データセット
uspto-grants-1992_11
特許番号
US05162322

反応ノート

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