Hydrochloric Acid → HCID 19811459、化合物

HRID 373028ノート

反応式

HRID 373028 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][CH:5]1[O:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:6]1.Cl.[CH2:18]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)[CH3:19].C(=O)([O-])[O-].[K+].[K+].[I-].[K+].Cl>C(O)CCC.C(OCC)C>[OH2:9].[ClH:1].[CH2:18]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:28][CH2:29][N:30]([CH2:2][CH2:3][CH2:4][CH:5]2[O:9][C:8](=[O:10])[N:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:6]2)[CH2:31][CH2:32]1)[CH3:19]

参加物

8

反応物 5

HCID 313Hydrochloric AcidHCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 128624181-(2-Ethoxyphenyl)piperazine HydrochlorideHCID 198114805-(3-Chloropropyl)-3-phenyl-2-oxazolidinone

生成物 1

HCID 19811459HCID 19811459、化合物収率 43%

試薬・触媒・溶媒 2

HCID 2631-Butanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

Following the procedure of Example 5, a mixture of 5-(3-chloropropyl)-3-phenyl-2-oxazolidinone (4.5 g, 0.0188 mol), 1-(2-ethoxyphenyl)piperazine hydrochloride (4.57 g, 0.0188 mol), potassium carbonate (10.42 ,g 0.0754 mol), and potassium iodide (1.0 g) in n-butanol (200 mL) gave an oil. Acidification with ethanolic hydrogen chloride followed by addition of diethyl ether gave a solid, which was collected by filtration and dried under high vacuum to give 3.97 g (43% yield), mp 182°-187° C.

後処理

  1. customgave an oil
  2. customgave a solid, which
  3. filtrationwas collected by filtration
  4. customdried under high vacuum
  5. customto give 3.97 g (43% yield), mp 182°-187° C.

出典と根拠

ORDレコード
ord-52904729fd384ee5b61e85733a6e19fe
出典データセット
uspto-grants-1992_11
特許番号
US05162322

反応ノート

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