反应详情

Following the procedure of Example 5, a mixture of 5-(3-chloropropyl)-3-phenyl-2-oxazolidinone (4.5 g, 0.0188 mol), 1-(2-ethoxyphenyl)piperazine hydrochloride (4.57 g, 0.0188 mol), potassium carbonate (10.42 ,g 0.0754 mol), and potassium iodide (1.0 g) in n-butanol (200 mL) gave an oil. Acidification with ethanolic hydrogen chloride followed by addition of diethyl ether gave a solid, which was collected by filtration and dried under high vacuum to give 3.97 g (43% yield), mp 182°-187° C.

1. customgave an oil
2. customgave a solid, which
3. filtrationwas collected by filtration
4. customdried under high vacuum
5. customto give 3.97 g (43% yield), mp 182°-187° C.