Hydrochloric Acid → 5-[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]-3-phenyl-2-oxazolidinone hydrochloride hydrate

HRID 373029ノート

反応式

HRID 373029 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][CH:5]1[O:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:6]1.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+].Cl>C(O)CCC>[OH2:9].[ClH:1].[CH3:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:30][CH2:29][N:28]([CH2:2][CH2:3][CH2:4][CH:5]2[O:9][C:8](=[O:10])[N:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:6]2)[CH2:27][CH2:26]1

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 13461-(2-Methoxyphenyl)piperazineHCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 198114805-(3-Chloropropyl)-3-phenyl-2-oxazolidinone

生成物 1

HCID 198114905-[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]-3-phenyl-2-oxazolidinone hydrochloride hydrate収率 53%

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

Following the procedure of Example 5, a mixture of 5-(3-chloropropyl)-3-phenyl-2-oxazolidinone (4.5 g, 0.0188 mol), 1-(2-methoxyphenyl)-piperazine (3.62 g, 0.0188 mol), potassium carbonate (7.81 g, 0.0565 mol), and potassium iodide (1.0 g) in n-butanol (200 mL) gave an oil. The oil was acidified with warm ethanolic hydrogen chloride, filtered warm, and cooled to room temperature. Diethyl ether was added and the resulting solid was collected by filtration and dried under high vacuum at 50° C. to give 4.65 g (53% yield), mp 203°-211° C.

後処理

  1. customgave an oil
  2. filtrationfiltered
  3. temperaturewarm
  4. additionDiethyl ether was added
  5. filtrationthe resulting solid was collected by filtration
  6. customdried under high vacuum at 50° C.
  7. customto give 4.65 g (53% yield), mp 203°-211° C.

出典と根拠

ORDレコード
ord-8b9a1b7580c84e5ebbbcfc00e7a96726
出典データセット
uspto-grants-1992_11
特許番号
US05162322

反応ノート

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