Boc-Beta-Ala-OSu → HCID 15940107, 화합물

HRID 373034노트

반응식

HRID 373034 반응식
[NH:1]([C:20]([O:22]C(C)(C)C)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5].[NH:27]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:28][CH2:29]C(ON1C(=O)CCC1=O)=O>>[NH:27]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:28][CH2:29][C:20]([NH:1][C@H:2]([C:7]([NH:9][C@H:10]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:11][CH:12]([CH3:13])[CH3:14])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5])=[O:22]

참가 물질

3

반응물 2

HCID 10684599Boc-Beta-Ala-OSuHCID 15003891HCID 15003891, 화합물

생성물 1

HCID 15940107HCID 15940107, 화합물수율 70.7%

실험 절차

Using 5.60 g of Boc-Asn-Leu-OEt and 5.60 g of Boc-β-Ala-OSu, the same procedure as in Reference Example 35 was repeated to obtain 4.71 g (yield: 70.6%) of the above objective compound having a melting point of 148°-153° C.

출처 및 근거

ORD 기록
ord-a5489522b48e4b6089e98f0a1c46a266
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05162305

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