Sulfuric Acid → HCID 67619766, compound

HRID 373081Notes

Reaction equation

HRID 373081 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[C:11]([NH:15][C:16]3[N:21]=[C:20]([C:22]4[S:23][CH:24]=[CH:25][CH:26]=4)[CH:19]=[CH:18][N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[S:27](=[O:31])(=[O:30])([OH:29])[OH:28]>C(O)C>[S:27]([OH:31])([OH:30])(=[O:29])=[O:28].[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[C:11]([NH:15][C:16]3[N:21]=[C:20]([C:22]4[S:23][CH:24]=[CH:25][CH:26]=4)[CH:19]=[CH:18][N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 9820417N-[3-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine

Product 1

HCID 67619766HCID 67619766, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 1.0 g of N-[3-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine in 10 ml of hot ethyl alcohol is added 5 ml of ethyl alcohol containing 0.27 g of sulfuric acid. Crystals begin to form and the reaction mixture is cooled. The solid is collected by filtration, washed with ethyl alcohol and dried to afford the desired product.

Workup

  1. customto form
  2. temperaturethe reaction mixture is cooled
  3. filtrationThe solid is collected by filtration
  4. washwashed with ethyl alcohol
  5. customdried

Sources & evidence

ORD record
ord-0ab7639cd477450fb09c079a0c709396
Source dataset
uspto-grants-1992_11
Patent number
US05162328

Reaction notes

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