Lactic Acid → HCID 19811568, compound

HRID 373084Notes

Reaction equation

HRID 373084 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[C:11]([NH:15][C:16]3[N:21]=[C:20]([C:22]4[S:23][CH:24]=[CH:25][CH:26]=4)[CH:19]=[CH:18][N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[C:27]([OH:32])(=[O:31])[CH:28]([CH3:30])[OH:29]>C(O)C>[OH:29][CH:28]([CH3:30])[C:27]([OH:32])=[O:31].[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[C:11]([NH:15][C:16]3[N:21]=[C:20]([C:22]4[S:23][CH:24]=[CH:25][CH:26]=4)[CH:19]=[CH:18][N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 612Lactic AcidHCID 9820417N-[3-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine

Product 1

HCID 19811568HCID 19811568, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 1.0 g of N-[3-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine in 10 ml of hot ethyl alcohol is added 5 ml of ethyl alcohol containing 0.25 g of lactic acid. Crystals begin to form and the reaction mixture is cooled. The solid is collected by filtration, washed with ethyl alcohol and dried to afford the desired product.

Workup

  1. customto form
  2. temperaturethe reaction mixture is cooled
  3. filtrationThe solid is collected by filtration
  4. washwashed with ethyl alcohol
  5. customdried

Sources & evidence

ORD record
ord-8392c3b338ad49e69d15dc3da6a989c5
Source dataset
uspto-grants-1992_11
Patent number
US05162328

Reaction notes

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