2,3-Dihydroxybutanedioic Acid → HCID 19811565, compound

HRID 373087Notes

Reaction equation

HRID 373087 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[C:11]([NH:15][C:16]3[N:21]=[C:20]([C:22]4[S:23][CH:24]=[CH:25][CH:26]=4)[CH:19]=[CH:18][N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[C:27]([OH:36])(=[O:35])[CH:28]([CH:30]([C:32]([OH:34])=[O:33])[OH:31])[OH:29]>C(O)C>[OH:31][CH:30]([CH:28]([OH:29])[C:27]([OH:36])=[O:35])[C:32]([OH:34])=[O:33].[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[C:11]([NH:15][C:16]3[N:21]=[C:20]([C:22]4[S:23][CH:24]=[CH:25][CH:26]=4)[CH:19]=[CH:18][N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 8752,3-Dihydroxybutanedioic AcidHCID 9820417N-[3-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine

Product 1

HCID 19811565HCID 19811565, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 1.0 q of N-[3-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine in 10 ml of hot ethyl alcohol is added 5 ml of ethyl alcohol containing 0.41 g of tartaric acid. Crystals begin to form and the reaction mixture is cooled. The solid is collected by filtration, washed with ethyl alcohol and dried to afford the desired product.

Workup

  1. customto form
  2. temperaturethe reaction mixture is cooled
  3. filtrationThe solid is collected by filtration
  4. washwashed with ethyl alcohol
  5. customdried

Sources & evidence

ORD record
ord-a463ce8eb76d47fb85399df54288d36f
Source dataset
uspto-grants-1992_11
Patent number
US05162328

Reaction notes

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