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Sodium hydride → 2-Butyl-6-methyl-3-[[4-(2-cyanopyridin-3-yl)phenyl]methyl]quinazolin-4(3H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 3-[4-(Bromomethyl)phenyl]-2-pyridinecarbonitrile | HCID 18384514 | — |
| 反応物 | HCID 178441839 | HCID 178441839 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Sodium chloride; water | HCID 57417360 | — |
| 生成物 | 2-Butyl-6-methyl-3-[[4-(2-cyanopyridin-3-yl)phenyl]methyl]quinazolin-4(3H)-one | HCID 19811513 | — |
反応手順
To a solution of 2-butyl-6-methylquinazolin-4(1H)-one (1.0 eq.) from Example 1 Step B in DMF at rt is added NaH (1.5 eq. of an 80% dispersion in oil). After 20 min, 2-cyano-3-(4-bromomethylphenyl)pyridine (1.2 eq.) is added and the mixture is stirred at rt for 3 h. Brine (100 mL) and aqueous NH4Cl (40 mL) are added and the product is extracted with EtOAc. Purification by flash chromatography gives the above titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05162325 |
| 出典データセット | uspto-grants-1992_11 |
| ORD ID | ord-58dae8270e5940adaf96ffe1afb7a2b3 |
| 出典メモ | uspto-grants-1992_11 |