1H-1,2,4-Triazole → HCID 19811978, compound

Participants

Reaction Conditions

Reaction Steps

13 g (188 mmol) of 1,2,4-triazole and 18 g (130 mmol) of potassium carbonate are initially introduced into 30 ml of absolute dimethylformamide under a nitrogen atmosphere and the mixture is heated to 80° C. At this temperature, a solution of 17.1 g (59.6 mmol) of 1-chloro-3-(2-chlorophenyl)-2-(1-methyl-cyclopent-1-yl)-propan-2-ol in 20 ml of absolute dimethylformamide is added dropwise with stirring. The reaction mixture is then stirred at 80° C. for a further 8 hours. The precipitate is filtered off with suction, and the filtrate is concentrated by stripping off the diluent under reduced pressure. The residue is taken up in ethyl acetate, washed with water and, after drying over sodium sulphate, the solvent is stripped off under reduced pressure. The product which remains is chromatographed through a silica gel column using dichloromethane/ethanol=99:1 as the eluent. 6.8 g (35.7% of theory) of 1-(2-chlorophenyl)-2-(1-methyl-cyclopent- 1-yl)-3-(1,2,4-triazol-1-yl)-propan-2-ol are obtained in this way in the form of a solid substance of melting point 110° C.

Provenance & Evidence