Dimethylamine → HCID 86746312, compound

Participants

Reaction Conditions

Reaction Steps

Pyridine hydrobromide perbromide (3.2 g) was added to a solution of 4-(2-formylphenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethylester (3.15 g) and pyridine (1.3 ml) in dicloromethane (100 ml) at 0° C. and stirred for 0.5 hours. The mixture was then cooled to -10° C., treated with dimethylamine (10.6 ml) and stirred at -10° C. for 1 hour. The solvent was evaporated and the residue taken up with ethyl acetate. The solid was filtered off and the solution evaporated to dryness to obtain a red oil, which was eluted on a silica gel column (Ethyl acetate/Petrol ether/Methanol, 7:3:1) to yield the title compound as a yellow solid (from petrol ether) (2.3 g), m.p. 115°-120° C. T.l.c. (CH2Cl2 /Methanol, 95:5) Rf. 0.38.

Provenance & Evidence