HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → HCID 19812057, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | HCID 19812072 | HCID 19812072 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 19812057 | HCID 19812057 | — |
Reaction Steps
The above alcohol (16.17 mmol) was oxidised using methods described in EP-A-164 187 (Swern oxidation, DMSO, oxalyl chloride, triethylamine) to give 8-(3',5'-bistrifluoromethylbenzyloxy)-octan-2-one. The ketone was reacted with triethyl-4-phosphonocrotonate/lithium diisopropylamide to give ethyl 11-(3',5'-bistrifluoromethyl)benzyloxy- 5-methylundeca-2,4-dienoate. The ester was converted into the amide as in Example 5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05162367 |
| Source dataset | uspto-grants-1992_11 |
| ORD ID | ord-b22368d5dce94bbf9bb6926e24aef25e |
| Source note | uspto-grants-1992_11 |