HCID 178439465, compound → HCID 178439466, compound

HRID 373236Notes

Reaction equation

HRID 373236 reaction equation
[O:1]=[C:2]1[N:7]([CH2:8][C:9]([O:11]C)=[O:10])[C:6](=[O:13])[CH:5]=[C:4]([CH2:14][CH2:15][CH3:16])[N:3]1[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[C:30]2[NH:34][N:33]=[N:32][N:31]=2)=[CH:20][CH:19]=1>CO.[OH-].[Na+]>[O:1]=[C:2]1[N:7]([CH2:8][C:9]([OH:11])=[O:10])[C:6](=[O:13])[CH:5]=[C:4]([CH2:14][CH2:15][CH3:16])[N:3]1[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[C:30]2[NH:34][N:33]=[N:32][N:31]=2)=[CH:20][CH:19]=1

Participants

4

Reactant 1

HCID 178439465HCID 178439465, compound

Product 1

HCID 178439466HCID 178439466, compoundYield 79%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of methyl 2,4-dioxo-6-propyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1,2,3,4-tetrahydropyrimidine-3-acetate (0.25 g) in methanol (10 ml) and 1N sodium hydroxide (1.5 ml) was heated under reflux for 16 hours. The reaction solution was evaporated to dryness and the residue was dissolved in water. The solution was acidified with 1N hydrochloric acid to give a crystalline product (0.19 g, 79%).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 16 hours
  3. customThe reaction solution was evaporated to dryness
  4. dissolutionthe residue was dissolved in water

Sources & evidence

ORD record
ord-eba49f7946f64a158a260a09a50b808d
Source dataset
uspto-grants-1992_11
Patent number
US05162326

Reaction notes

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