Potassium Carbonate → HCID 19811518, compound

Participants

Reaction Steps

A mixture of 6-chloro-5-phenyl-3-propyl-pyrimidine-2,4(1H,3H)-dione (0.5 g), 4-bromomethyl-2'-(N-trityltetrazol-5yl)biphenyl (1.11 g) and potassium carbonate (0.32 g) in DMF (20 ml) was stirred at room temperature for 22 hours. The reaction mixture was concentrated to dryness in vacuo and then the residue was dissolved in methylene chloride. The insoluble material was removed from the reaction mixture by filtration and the filtrate was concentrated to dryness. The resulting residue was purified by column chromatography on silica gel to give colorless amorphous powders (0.67 g, 48%).

Provenance & Evidence