Sodium borohydride → HCID 131717630, compound

Participants

Reaction Steps

(1S,5S,6S,7R)-3-[4-Methoxycarbonyl-1(EZ)-butenyl]-6-[4(RS)-fluoro-3-oxo-(E )-1-octenyl]-7-tetrahydropyranyloxybicyclo[3.3.0]oct-2-ene bicyclo[3.3.0]oct-2-ene (5) (0.088g) was dissolved in methanol. Into the solution, sodium borohydride (0.008 g) was added at 0° C. and the mixture was stirred for 30 minutes. The reaction mixture was treated by a usual manner to give (1S,5S,6S,7R)-3-[4-methoxycarbonyl-1(EZ)-butenyl]-6-[4(RS)-fluoro-3(R S)-hydroxy-(E)-1-octenyl]-7-tetrahydropyranyloxybicyclo[3.3.0]oct-2-ene (5") as a colorless oily product. Yield: 0.089 g

Provenance & Evidence