Sodium borohydride → HCID 131717632, compound

Participants

Reaction Steps

(1S,5S,6S,7R)-3-[4-Methoxycarbonyl-1(EZ)-butenyl]-6-[4,4-difluoro-3-oxo-(E )-1-octenyl]-7-tetrahydropyranyloxy-bicyclo[3.3.0]oct-2-ene (16) (0.196 g) was dissolved in methanol. To the solution, sodium borohydride (0.015 g) was added at 0° C., and the mixture was stirred for 30 minutes. After a usual work-up (1S,5S,6S,7R)-3-[4-methoxycarbonyl-1(EZ)-butenyl]-6-[4, 4-difluoro-3-(RS)hydroxy-(E)-1--octenyl]-7-tetrahydropyranyloxy-bicyclo[3.3.0]oct-2-ene (17) was obtained as a colorless oily product. Yield: 0.184 g (93%)

Provenance & Evidence