Sodium Hydroxide → HCID 86745715, compound

Participants

Reaction Steps

(1S,2S,3R,5S)-(E)-7-(4-Methoxycarbonylbutylidene)-2-[4,4-difluoro-3(RS)-hydroxy-(E )-1-octenyl]-3-tetrayhydropyranyloxybicyclo[3.3.0]octane (18) (0.175 g) was dissolved into methanol. To the solution, 1N aqueous solution of sodium hydroxide was added, and the mixture was stirred until it became completely clear. After a usual work-up a crude product, (1S,2S,3R,5S)-(E)-7-(4-carboxybutylidene)-2-[4,4-difluoro-3(R S)-hydroxy-(E)-1-octenyl]-3-tetrahydropyranyloxybicyclo[3.3.0]octane (19), was obtained. Yield: 0.172 g

Provenance & Evidence