Morpholine → HCID 10401503, compound

Participants

Reaction Steps

A mixture of 10 g 2-chloro-3-cyano-5,4'-bipyridine-1'-oxide and 40 ml morpholine is heated for 10 minutes at 70° C.-80° C. Subsequently, the mixture is evaporated to dryness under vacuum at an 80° C. bath temperature and the residue is collected, washed carefully with water and dried at 110° C. The product is refluxed for 1 hour with 150 ml dichloromethane, filtered off with suction, dried once again at 110° C. and crystallized from n-butyl acetate. Yield: 9.27 g (75% of the theoretical yield), with a melting point of 234° C.-236° C.

Provenance & Evidence