Ethanolamine → HCID 178509484, compound

HRID 373312Notes

Reaction equation

HRID 373312 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][C:5]([C:10]2[CH:15]=[CH:14][N+:13]([O-:16])=[CH:12][CH:11]=2)=[CH:4][N:3]=1.[CH2:17]([CH2:19][NH2:20])[OH:18]>C(O)C>[C:8]([C:7]1[C:2]([NH:20][CH2:19][CH2:17][OH:18])=[N:3][CH:4]=[C:5]([C:10]2[CH:15]=[CH:14][N+:13]([O-:16])=[CH:12][CH:11]=2)[CH:6]=1)#[N:9]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 10243008HCID 10243008, compound

Product 1

HCID 178509484HCID 178509484, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5 g 2-Chloro-3-cyano-5,4'-bipyridine-1'-oxide and 8 ml ethanolamine are refluxed in 50 ml ethanol for 4 hours and then concentrated under vacuum. The residue is taken up in water, filtered off with suction, washed with water, dried at 110° C. and crystallized from ethanol/glacial acetic acid with addition of activated charcoal. Yield: 4.5 g (81.3% of the theoretical yield), with a melting point of 229° C.-231° C.

Workup

  1. concentrationconcentrated under vacuum
  2. filtrationfiltered off with suction
  3. washwashed with water
  4. customdried at 110° C.
  5. customcrystallized from ethanol/glacial acetic acid with addition of activated charcoal
  6. customYield: 4.5 g (81.3% of the theoretical yield), with a melting point of 229° C.-231° C.

Sources & evidence

ORD record
ord-190aa47c2dc74cf384fd93408fbd723c
Source dataset
uspto-grants-1992_11
Patent number
US05162533

Reaction notes

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