Diethyl Ether → HCID 19391800, compound

Alkene ketal, 4(5-hexenyl)-2,2-dimethyl-1,3-dioxolane, (0.01 mole) was dissolved in ether (50 mL) in a flask equipped with dropping funnel, condenser and magnetic stirrer. A steady stream of dry nitrogen was bubbled through the solution. The dropping funnel was charged with borane methylsulfide (Aldrich Chemical Co., Milwaukee, Wis.) (5 mL) in ether (25 mL) and added dropwise to the alkene ketal solution over 30 mins. and the resulting mixture allowed to warm to room temperature and stirred for 3 hrs. Ethanol was then added to scavenge excess borane followed by sodium hydroxide (5 mL of 3 molar solution) and the resulting solution cooled in an ice bath before hydrogen peroxide (19 mL 30% solution) was added at such a rate that the reaction temperature did not exceed 35° C. After addition of the hydrogen peroxide was completed the reaction mixture was refluxed for 1 hr before it was poured over an ice/water (120 mL) mixture. The mixture was saturated with sodium chloride and extracted with ether. The extract was then dried over anhydrous sodium carbonate. The desired product (1.3 g) was obtained on evaporation of ether.

1. customequipped
2. customA steady stream of dry nitrogen was bubbled through the solution
3. additionThe dropping funnel was charged with borane methylsulfide (Aldrich Chemical Co., Milwaukee, Wis.) (5 mL) in ether (25 mL)
4. additionadded dropwise to the alkene ketal solution over 30 mins
5. additionEthanol was then added
6. temperaturethe resulting solution cooled in an ice bath before hydrogen peroxide (19 mL 30% solution)
7. additionwas added at such a rate that the reaction temperature
8. customdid not exceed 35° C
9. additionAfter addition of the hydrogen peroxide
10. temperaturewas refluxed for 1 hr before it
11. additionwas poured over an ice/water (120 mL) mixture
12. extractionextracted with ether
13. dry with materialThe extract was then dried over anhydrous sodium carbonate

ORD record

ord-5dfd5a03e5bf4757999199492c1e7222

Source dataset

uspto-grants-1992_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05163060