反应详情

198 g (1 mol) of 1-acetylamino-2-fluoro-4-nitrobenzene are transferred into a stainless steel autoclave together with 510 ml of methanol, about 3 g of palladium-on-charcoal (5%) are added and catalytic reduction is carried out in the course of 4 hours at 50° C. under a hydrogen pressure of 15 bar. After the catalyst has been removed, 450 ml of methanol are distilled off from the reaction solution in vacuo, the product which has precipitated is filtered off with suction and the residue is washed with a little methanol and dried at 50°-60° C. in a vacuum cabinet.

1. additionare added
2. customis carried out in the course of 4 hours at 50° C. under a hydrogen
3. customAfter the catalyst has been removed
4. distillation450 ml of methanol are distilled off from the reaction solution in vacuo
5. customthe product which has precipitated
6. filtrationis filtered off with suction
7. washthe residue is washed with a little methanol
8. customdried at 50°-60° C. in a vacuum cabinet