Water → HCID 14817080, compound

HRID 373443Notes

Reaction equation

HRID 373443 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[C:4]([F:12])[CH:3]=1.O.[C:14](OC(=O)C)(=[O:16])[CH3:15]>C(O)(=O)C>[C:9]([NH:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:14](=[O:16])[CH3:15])=[CH:3][C:4]=1[F:12])(=[O:11])[CH3:10]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 255648n-(4-Amino-2-fluorophenyl)acetamide

Product 1

HCID 14817080HCID 14817080, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
15 °C

Procedure

134.5 g (0.8 mol) of the 1-amino-4-acetylamino-3-fluorobenzene prepared above under A. are heated at 85° C. together with 800 ml of water and 34 g of acetic acid. 86.5 g of acetic anhydride are added to this mixture in the course of one hour. The reaction mixture is subsequently stirred at the same temperature for a further hour and cooled to 15° C. The product which has precipitated is then filtered off, washed twice with 150 ml of water each time and dried.

Workup

  1. customThe product which has precipitated
  2. filtrationis then filtered off
  3. washwashed twice with 150 ml of water each time
  4. customdried

Sources & evidence

ORD record
ord-af46820c16b94459930855801c4df6e6
Source dataset
uspto-grants-1992_11
Patent number
US05163970

Reaction notes

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