4,4'-Dihydroxybiphenyl → HCID 19809919, compound

Participants

Reaction Steps

a solution of 22.7 g of DCCI in 20 ml of CH2Cl2 is added at 0° to a mixture of 18.6 g of 4,4'-dihydroxy-1,1'-biphenyl, 15.5 g of (S)-2-cyano-2-methylhexanoic acid, 1.2 g of 4-dimethylaminopyridine and 100 ml of CH2Cl2, and the mixture is stirred at room temperature for 2 hours. The precipitate is filtered off with suction, the filtrate is concentrated and chromatography over silica gel gives 4'-(2-cyano-2-methylhexanoyloxy)-4-hydroxy-1,1'-biphenyl (optically active).

Provenance & Evidence