HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic Acid → 3-[4-Bromo-5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic Acid | HCID 188850 | — |
| Reactant | HCID 14497416 | HCID 14497416 | — |
| Reactant | 4-Bromo-5-(4-chlorophenyl)-3-(3-hydroxypropyl)-1-(4-methoxyphenyl)pyrazole | HCID 14497568 | — |
| Product | 3-[4-Bromo-5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-propionic acid | HCID 14497566 | — |
Reaction Steps
Substituting Compound 2 for the acid 12 in Example 37 afforded 4-bromo-5-(4-chlorophenyl)-3-(3-hydroxypropyl)-1-(4-methoxyphenyl)pyrazole (Compound No. 183), as an off-white solid, 87%, mp=118.5°-120°. MS, m/e 420 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05164381 |
| Source dataset | uspto-grants-1992_11 |
| ORD ID | ord-3f02f4cc7e88499b911f566cb7c57a37 |
| Source note | uspto-grants-1992_11 |