huagongshe.com
HRID373502

反应详情

EQUATION

反应方程式

HRID 373502 的结构方程式

REACTANTS

反应物

2
结构：O=S(Cl)Cl
HCID24386

Thionyl chloride

Cl2OS

结构：O=C1NC(=O)[C@@]2(C[C@@H](C(=O)O)Oc3ccc(F)cc32)N1
HCID9838583

(2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxylic acid

C12H9FN2O5

PRODUCTS

生成物

1
结构：O=C1NC(=O)[C@@]2(C[C@@H](C(=O)Cl)Oc3ccc(F)cc32)N1
HCID57210646

未命名化合物

PROCEDURE

实验过程

To thionyl chloride (24.9 ml, 3.57 mol) was added (2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxylic acid (20.0 g, 71.4 mmol). After refluxing the mixture under argon atmosphere for 22 hours, the excess thionyl chloride was evaporated in vacuo to dryness to give quantitatively crude crystals of (2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carbonyl chloride.

WORKUP

后处理

  1. temperatureAfter refluxing the mixture under argon atmosphere for 22 hours
  2. customthe excess thionyl chloride was evaporated in vacuo to dryness