Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(2-Aminoethyl)-1-(3,4,5-trimethoxycinnamoyl)piperazine → (2S,4S)-N-{2-[4-(3,4,5-Trimethoxycinnamoyl)piperazin-1-yl]ethyl}-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(2-Aminoethyl)-1-(3,4,5-trimethoxycinnamoyl)piperazine | HCID 54446348 | — |
| 반응물 | (2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carbonyl chloride | HCID 57210646 | — |
| 생성물 | (2S,4S)-N-{2-[4-(3,4,5-Trimethoxycinnamoyl)piperazin-1-yl]ethyl}-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide | HCID 67916664 | 72% |
반응 단계
The procedure similar to that described in Example 8 was carried out with the use of the compound of 4-(2-aminoethyl)-1-(3,4,5-trimethoxycinnamoyl)piperazine and (2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carbonyl chloride (Reference Example 1) to give the desired compound with yield of 72.0%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05164391 |
| 출처 데이터셋 | uspto-grants-1992_11 |
| ORD ID | ord-701d41924cfc4bd2932e44dc7912fdc5 |
| 출처 메모 | uspto-grants-1992_11 |