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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 373521Generated: October 29, 2026

1-Methylpiperazine → 5-Amino-1-cyclopropyl-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

https://huagongshe.com/reaction/373521

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylpiperazineHCID 53167—
Reactant5-Amino-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 14880209—
Product5-Amino-1-cyclopropyl-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 14880224—

Reaction Steps

5-Amino-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 1-methylpiperazine were reacted and worked up in the same way as in Example 1 to give 5-amino-1-cyclopropyl-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid. m.p. 216°-218° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05164392
Source datasetuspto-grants-1992_11
ORD IDord-a502e7951d5c4cb6994ee115bdb1972b
Source noteuspto-grants-1992_11