HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclopropyl-5,6-difluoro-7-(3-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 5-Amino-1-cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclopropyl-5,6-difluoro-7-(3-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 15729413 | — |
| Reactant | Ammonia dimethylformamide | HCID 17875328 | — |
| Product | 5-Amino-1-cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 14880226 | — |
Reaction Steps
In a sealed tube, 1-cyclopropyl-5,6-difluoro-7-(3-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid was aminated with ammonia/dimethylformamide as in Example 13 to give 5-amino-1-cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid. m.p. 181°-183° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05164392 |
| Source dataset | uspto-grants-1992_11 |
| ORD ID | ord-a968df53793e422a83bec0a55f0baac0 |
| Source note | uspto-grants-1992_11 |