Malonic Acid → HCID 19810666, compound

HRID 373532Notes

Reaction equation

HRID 373532 reaction equation
[CH:1]1([CH2:4][NH:5][C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:7])[CH2:3][CH2:2]1.[C:15](O)(=[O:20])[CH2:16][C:17](O)=[O:18].C(O[C:26](=[O:28])[CH3:27])(=O)C>>[C:9]1([N:8]2[C:15](=[O:20])[CH:16]([C:26](=[O:28])[CH3:27])[C:17](=[O:18])[N:5]([CH2:4][CH:1]3[CH2:3][CH2:2]3)[C:6]2=[O:7])[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 3

HCID 867Malonic AcidHCID 7918Acetic AnhydrideHCID 2815427HCID 2815427, compound

Product 1

HCID 19810666HCID 19810666, compound

Procedure

A quantity of 4.75 g of 1-cyclopropylmethyl-3-phenyl urea and 2.60 g of malonic acid are heated in 30 ml of acetic acid anhydride at 75° C. for 4 hours. After cooling slowly, the acetic acid anhydride is evaporated in vacuo. The residue is boiled in ethanol, cooled and filtered. The resulting crystalline product is the title compound (5) and melts at 91°-95° C.; yield 5.21 g.

Workup

  1. temperatureAfter cooling slowly
  2. customthe acetic acid anhydride is evaporated in vacuo
  3. temperaturecooled
  4. filtrationfiltered

Sources & evidence

ORD record
ord-7ff0f01b82184cbc93a56b40cc65f4ab
Source dataset
uspto-grants-1992_11
Patent number
US05164396

Reaction notes

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