Water → HCID 54078692, compound

HRID 373591Notes

Reaction equation

HRID 373591 reaction equation
C[O-].[Na+].Cl[CH:5]([N:21]1[CH:25]=[N:24][CH:23]=[N:22]1)[CH:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[F:20])[C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1.O>CO.[I-].[K+]>[N:21]1([CH:5]=[C:6]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])[C:7]2[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=2)[CH:25]=[N:24][CH:23]=[N:22]1

Participants

6

Reactant 3

HCID 962WaterHCID 10942334Sodium MethoxideHCID 19810730HCID 19810730, compound

Product 1

HCID 54078692HCID 54078692, compoundYield 89.3%

Reagents, catalysts & solvents 2

HCID 4875Potassium IodideCatalystHCID 887MethanolSolvent

Procedure

28.6 g of sodium methylate and 0.2 g of potassium iodide are added to a solution of 84.7 g of 1-chloro-1(1,2,4-triazol-1-yl)-2-(2-fluorophenyl)-2-(4-fluorophenyl)-ethane in 500 ml of methanol. After the reaction mixture has been refluxed for one hour, 300 ml of water are added to the solution, which is extracted several times by shaking with methyl tert-butyl ether. The organic phase separated off is washed twice with water, then dried over sodium sulfate and evaporated down, 67 g (89%) of 1-(1,2,4-triazol-1-yl)-2-(2-fluorophenyl)-2-(4-fluorophenyl)-ethene being obtained in the form of an oil.

Workup

  1. temperatureAfter the reaction mixture has been refluxed for one hour
  2. extractionis extracted several times
  3. customThe organic phase separated off
  4. washis washed twice with water
  5. dry with materialdried over sodium sulfate
  6. customevaporated down

Sources & evidence

ORD record
ord-399ea206e3ff4fc9b4d73c2fdb65e2c5
Source dataset
uspto-grants-1992_11
Patent number
US05164408

Reaction notes

Loading…