Benzyl Alcohol → HCID 19810564, compound

Participants

Reaction Steps

The methyl ester (4 g, 18 mmol) from the above reaction was dissolved in 10 ml of benzyl alcohol and 50 ml of Benzene. After adding TsOH.H2O (0.5 g, 2.63 mmol), the contents were heated under reflux for 2 h. Once the required amount of H2O had been collected, the solution was concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel, Hexane-AcOEt, 3:1) which gave 3.8 g (71%) of the title compound: 7.40-7.10 (m,10H), 5.03 (s,2H), 3.57 (t,J=6Hz,2H), 3.00-2.60 (m,≈4H), and 1.80-1.40 (m,4H).

Provenance & Evidence