Hexane → HCID 19811009, compound

Participants

Reaction Steps

8 cm3 of a 1.5M solution of n-butyllithium in n-hexane is poured into a solution comprising 1.02 g, or 0.9 cm3, of 2-pyrrolidinone in 50 cm3 of tetrahydrofuran, cooled to -70° C., without the temperature exceeding -60° C. After 15 minutes, 3 g of benzenesulphonyl-4-cyclopentyl chloride in solution in 12 cm3 of tetrahydrofuran is added, maintaining the temperature between -65° and -70° C. After allowing to return to ambient temperature over 2 hours and evaporating to dryness, the residue is chromatographed on silica (eluent: ethyl acetate-n-hexane 1-3) and 2.6 g of expected product is obtained.

Provenance & Evidence