Potassium Hydroxide → HCID 18649006, compound

Participants

Reaction Steps

N-CBZ-L-Valyl-N-(2-indanyl)glycine ethyl ester (13.8 g, 0.0305 mol) was dissolved in ethanol (200 mL) and treated with 1N KOH (30 mL) in 5 mL portions. After the mixture was allowed to sit at room temperature overnight, the ethanol was removed under vacuum, and the residue treated with water. The aqueous mixture was washed three times with ethyl acetate and the layers separated. The aqueous layer was acidified to pH 3 with 1N HCl. The product was extracted into ethyl acetate and washed with saturated aqueous NaCl-solution. After drying over MgSO4, filtration and evaporation under reduced pressure afforded the product as a white semi-solid (9.1 g).

Provenance & Evidence