Hydrochloric Acid → HCID 19958555, compound

Participants

Reaction Steps

The above ester (1.5 g, 5 mmol) was suspended in 70 ml of 2.5% NaOH and 30% H2O2 (1.95 ml) was added. The mixture was warmed at 70°-80° C. for 5 h, cooled and acidified (pH=1) with concentrated hydrochloric acid. The precipitate was filtered off and recrystallized from DMF-water to afford 1.17 g (81%) of the title compound. M.p. 317°-19° C. 1H-NMR (DMSO-d6):δ4.95 (s, 2H), 7.36 (s, 1H), 7.72 (s, 1H), 12.13 (s, 1H), 13.32 (br.s, 1H).

Provenance & Evidence