Ammonia → HCID 19775889, compound

Participants

Reaction Steps

51 g of 1-[4-(3-chlorophenoxy)-phenoxy]-2-propanone are dissolved in 510 ml of methanol in an autoclave, and 10 g of Raney nickel are added. 31 g of liquid ammonia are introduced, and then hydrogen gas is introduced under pressure. The reaction mixture is hydrogenated at 50 bar and +40° C.-45° C. for 2 hours. The reaction mixture is then filtered through diatomaceous earth and the solvent is distilled off completely in vacuo. The crude product is chromatographed over silica gel (eluant: diethyl ether/methanol, 9:1), yielding pure 2-amino-1-[4-(3-chlorophenoxy)-phenoxy]-propane in the form of a colourless, oily liquid, n20D : 1.5743.

Provenance & Evidence