反应详情

温度

50 °C

A mixture of 13.8 g of 6-chloro-N-methyl-3-pyridinemethanamine, 10.8 g of S-methyl-N-nitroisothiourea and 60 ml of ethanol was heated at 50° C. with stirring for 2 hours and then refluxed for additional 5 hours. After cooling, the separated crystal was collected by filtration, washed with a small amount of ethanol, and dried to obtain 14.7 g of the title compound. This compound is No.1 in Table 1. m.p.: 158.0° C. (Decomposed).

1. temperaturerefluxed for additional 5 hours
2. temperatureAfter cooling
3. filtrationthe separated crystal was collected by filtration
4. washwashed with a small amount of ethanol
5. customdried