反应详情

A mixture of 1.50 g of 2-chloro-N-methyl-5-thiazolemethanamine, 1.13 g of S-methyl-N-nitroisothiourea and 6 ml of ethanol was heated under reflux for 6 hours. After cooling, the reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (Solvent: Chloroform/Methanol=20/1) to obtain 1.00 g of the title compound as crystals. This compound is No. 6 in Table 1. m.p.: 116.0°-117.0° C.

1. temperaturewas heated
2. temperatureunder reflux for 6 hours
3. temperatureAfter cooling
4. concentrationthe reaction mixture was concentrated under reduced pressure
5. customthe residue was purified by silica gel column chromatography (Solvent: Chloroform/Methanol=20/1)