反应详情

A mixture of 0.48 g of 2-chloro-5-thiazolemethanamine, 0.31 g of S-methyl-N-methyl-N'-nitroisothiourea prepared by the method described in the Journal of Medical Chemistry., 1977, Vol. 20, No. 7, P. 905 and 3 ml of ethanol was heated under reflux for 6 hours. After cooling, the reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (Solvent: Chloroform/Methanol =20/1) to obtain 0.37 g of the title compound as crystals. This compound is No. 8 in Table 1. m.p.: 151.0°-153.0° C.

1. customprepared by the method
2. temperatureunder reflux for 6 hours
3. temperatureAfter cooling
4. concentrationthe reaction mixture was concentrated under reduced pressure
5. customthe residue was purified by silica gel column chromatography (Solvent: Chloroform/Methanol =20/1)