2-Chloro-5-aminomethylthiazole → HCID 178512119, compound

HRID 373796Notes

Reaction equation

HRID 373796 reaction equation
[Cl:1][C:2]1[S:3][C:4]([CH2:7][NH2:8])=[CH:5][N:6]=1.CS[C:11](=[NH:16])[NH:12][N+:13]([O-:15])=[O:14]>C(O)C>[Cl:1][C:2]1[S:3][C:4]([CH2:7][NH:8][C:11]([NH:12][N+:13]([O-:15])=[O:14])=[NH:16])=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 101541292-Chloro-5-aminomethylthiazoleHCID 135927615N-Nitro-S-methylisothiourea

Product 1

HCID 178512119HCID 178512119, compoundYield 77.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.35 g of 2-chloro-5-thiazolemethanamine, 0.31 g of S-methyl-N-nitroisothiourea and 3 ml of ethanol was heated under reflux for 6 hours. After cooling, the separated crystals were collected by filtration, washed with a small amount of ethanol, and then recrystalized from ethanol to obtain 0.42 g of the title compound as crystals. This compound is No. 9 in Table 1. m.p.: 160.0°-162.0° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 6 hours
  3. temperatureAfter cooling
  4. filtrationthe separated crystals were collected by filtration
  5. washwashed with a small amount of ethanol
  6. customrecrystalized from ethanol

Sources & evidence

ORD record
ord-fb63050e9fa5456a8552b8882c521497
Source dataset
uspto-grants-1992_11
Patent number
US05166164

Reaction notes

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