反应详情

A mixture of 0.35 g of 2-chloro-5-thiazolemethanamine, 0.31 g of S-methyl-N-nitroisothiourea and 3 ml of ethanol was heated under reflux for 6 hours. After cooling, the separated crystals were collected by filtration, washed with a small amount of ethanol, and then recrystalized from ethanol to obtain 0.42 g of the title compound as crystals. This compound is No. 9 in Table 1. m.p.: 160.0°-162.0° C.

1. temperaturewas heated
2. temperatureunder reflux for 6 hours
3. temperatureAfter cooling
4. filtrationthe separated crystals were collected by filtration
5. washwashed with a small amount of ethanol
6. customrecrystalized from ethanol