Ammonium Hydroxide → HCID 19761401, compound

Participants

Reaction Steps

To polyphosphoric acid (30 ml) preheated to 110° C. was added 1.95 g 1-(2-amino-5-methoxyphenyl)ethanone phenylhydrazone in small portions under N2. The reaction was maintained at 110°-120° C. for forty-five minutes. This mixture was poured directly into excess water and made basic with concentrated NH4OH. Extraction with dichloromethane, drying (MgSO4) and concentration yielded 1.5 g 2-(2-amino-5-methoxyphenyl)-1H-indole as a solid, m.p. 97°-99° C.

Provenance & Evidence