HCID 19761446, compound → HCID 19761437, compound

Participants

Reaction Steps

A total of 123 ml 1M LiAlH4 in THF was added portionwise to a solution of 15.37 g N-[2-(1H-indol-2-yl)-4-chlorophenyl]formamide in 230 ml THF, during which the temperature was maintained below 20° C. The resulting mixture was stirred three hours at room temperature and then quenched with a saturated NH4Cl solution (140 ml). This was then filtered through celite, dried (MgSO4), and concentrated to yield a solid. Purification by HPLC using CH2Cl2 /hexane (2:3) as eluent yielded 7.43 g solid, m.p. 123°-126°.

Provenance & Evidence